Discovery Guides Areas


STD Protection With or Without Contraception

(Released January 2002)

  by Robert Lessick  


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  Attitudes & Behavior Nonoxynol-9
  1. Protegrin structure and activity against Neisseria gonorrhoeae
    Infection and Immunity [Infect. Immun.], vol. 65, no. 2, pp. 636-639, Feb 1997

  2. Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: Potential applications to microbicide development
    Antimicrobial Agents & Chemotherapy [Antimicrob. Agents Chemother.], vol. 41, no. 7, pp. 1521-1530, Jul 1997

  3. Effect of undecylenic acid as a topical microbicide against genital herpes infection in mice and guinea pigs
    Antiviral Research [Antiviral Res.], vol. 40, no. 3, pp. 139-144, 1 Jan 1999

  4. Bile salts: Natural detergents for the prevention of sexually transmitted diseases
    Antimicrobial Agents & Chemotherapy [Antimicrob. Agents Chemother.], vol. 43, no. 4, pp. 745-751, Apr 1999

  5. Plant products as topical microbicide candidates: assessment of in vitro and in vivo activity against herpes simplex virus type 2
    Antiviral Research [Antiviral Res.], vol. 42, no. 3, pp. 219-226, 1 Jul 1999

  6. Hydrogels Containing Monocaprin Prevent Intravaginal and Intracutaneous Infections With HSV-2 in Mice: Impact on the Search for Vaginal Microbicides
    Journal of Medical Virology [J. Med. Virol.], vol. 61, no. 1, pp. 107-110, May 2000

  7. Dendrimers, a new class of candidate topical microbicides with activity against herpes simplex virus infection
    Antimicrobial Agents & Chemotherapy [Antimicrob. Agents Chemother.], vol. 44, no. 9, pp. 2471-2474, Sep 2000

  8. Transgenic commensals as mucosal protectants
    Nature Biotechnology [Nat. Biotechnol.], vol. 18, no. 10, pp. 1038-1039, Oct 2000

  9. In vitro inactivation of Chlamydia trachomatis and of a panel of DNA (HSV-2, CMV, adenovirus, BK virus) and RNA (RSV, enterovirus) viruses by the spermicide benzalkonium chloride
    Journal of Antimicrobial Chemotherapy [J. Antimicrob. Chemother.], vol. 46, no. 5, pp. 685-693, Nov 2000

  10. Candidate Microbicides Block HIV-1 Infection of Human Immature Langerhans Cells within Epithelial Tissue Explants
    Journal of Experimental Medicine [J. Exp. Med.], vol. 192, no. 10, pp. 1491-1500, 20 Nov 2000

  11. Thermoreversible gel as a candidate barrier to prevent the transmission of HIV-1 and herpes simplex virus type 2.
    Sexually transmitted diseases., 2001 Aug, 28(8):484-91

  12. Preclinical evaluation of docusate as protective agent from herpes simplex viruses
    Antiviral Research [Antiviral Res.], vol. 52, no. 1, pp. 25 - 32, 1 Oct 2001

  13. In vitro and in vivo evaluations of sodium lauryl sulfate and dextran sulfate as microbicides against herpes simplex and human immunodeficiency viruses
    Journal of Clinical Microbiology [J. Clin. Microbiol.], vol. 38, no. 1, pp. 110-119, Jan 2000

  14. Sodium lauryl sulfate abrogates human immunodeficiency virus infectivity by affecting viral attachment
    Antimicrobial Agents & Chemotherapy [Antimicrob. Agents Chemother.], vol. 45, no. 8, pp. 2229-2237, Aug 2001

  15. A broad-spectrum microbicide with virucidal activity against sexually transmitted viruses
    Antimicrobial Agents & Chemotherapy [Antimicrob. Agents Chemother.], vol. 43, no. 2, pp. 314-321, Feb 1999

  16. Design of a "Microbicide" for Prevention of Sexually Transmitted Diseases Using "Inactive" Pharmaceutical Excipients
    Biologicals, vol. 27, no. 1, pp. 11-21, Mar 1999

  17. Effect of a cellulose acetate phthalate topical cream on vaginal transmission of simian immunodeficiency virus in rhesus monkeys
    Antimicrobial Agents & Chemotherapy [Antimicrob. Agents Chemother.], vol. 44, no. 11, pp. 3199-3202, Nov 2000

  18. Preliminary safety and acceptability of a carrageenan gel for possible use as a vaginal microbicide.
    Sex Transm Infect, 2000 Dec, 76(6):480-3

  19. Tests of Buffergel for contraception and prevention of sexually transmitted diseases in animal models.
    Sexually transmitted diseases., 2001 Jul, 28(7):417-23

  20. Phase 1 Trial of the Topical Microbicide BufferGel: Safety Results From Four International Sites
    JAIDS Journal of Acquired Immune Deficiency Syndromes [Jaids J. Acquired Immune Defic. Syndromes], vol. 26, no. 1, pp. 21-27, Jan 2001

  21. Safety and Tolerability of BufferGel, a Novel Vaginal Microbicide, in Women in the United States
    Clinical Infectious Diseases [Clin. Infect. Dis.], vol. 32, no. 3, pp. 476-482, 1 Feb 2001