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Immunology Abstracts

  
 
Immunology ranks as one of the most rapidly expanding areas of biomedical science, covering topics from cancer and vaccine research to immune deficiencies and autoimmunity. Immunology Abstracts performs a vital function for scientists in this field by monitoring significant advances and bringing together diverse research results in one succinct journal. Studies relating to all aspects of immune systems in man and animals, in normal functions and disorders, are summarized. Concentrating on basic science research and its clinical implications. Researchers working in a wide range of biomedical fields will find information essential to their work summarized in this database.

Subject Coverage
    Major areas of coverage include:
    • Apoptosis
    • Autoimmunity
    • Complement
    • Cytokines and chemokines
    • Genetics
    • Histocompatibility antigen systems
    • Hypersensitivity
    • Immune response against microorganisms
    • Immunization (passive and active)
    • Immunodeficiency and immunoproliferation
    • Immunomodulation
    • Immunopharmacology
    • Inflammation
    • Lymphoid organs, tissues, and cells
    • Methodology
    • Parasite immunology
    • Reproductive immunology
    • Transplantation
    • Tumor immunology and immunotherapy
Dates of Coverage
    1982 - current
Update Frequency
    Monthly, with approximately 1,500 new records added
Size
    Over 0 records as of May 2013
Print Equivalent
    Immunology Abstracts (1982 - 2003)
Supplier
    Proquest
    789 E. Eisenhower Parkway
    P.O. Box 1346
    Ann Arbor, MI 48106-1346
    Tel: +1-734-761-4700
Sample Record

    TI:

    Title
    IL-7 Is a Critical Factor in Modulating Lesion Development in Skn-Directed Autoimmunity

    AU:

    Author
    Staton, Pamela J; Carpenter, ABetts; Jackman, Susan H

    AF:

    Author Affiliation
    Departments of Microbiology, Immunology, and Molecular Genetics and Department of Pathology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25704

    SO:

    Source
    Journal of Immunology [J. Immunol.]. Vol. 176, no. 7, pp. 3978-3986. 1 Apr 2006.

    IS:

    ISSN
    0022-1767

    DE:

    Descriptors
    Interleukin 7; Spleen; CD4 antigen; Autoimmunity; Lymphocytes T; Development; Adoptive transfer; Immunoregulation; Skin diseases; CD8 antigen; Animal models

    AB:

    Abstract
    In a murine model of autoimmunity targeted against the epidermal cell Ags, Skn, adoptive transfer of Skn-immune T cells to immunosuppressed recipients elicits skin lesions in areas of mild epidermal trauma. In this study, we examined peripheral regulation of Skn-induced autoreactivity disrupted by rendering the mice immunoincompetent. We found that regulation of Skn-directed autoimmunity was restored by cotransfer of normal syngeneic spleen cells at twice the concentration of Skn-immune cells and was evidenced by significantly reduced lesion severity by days 5-7 post-cotransfer compared with animals given injections of Skn-immune cells alone. Enrichment and depletion of normal CD4 super(+) or CD8 super(+) spleen cells and RT-PCR analysis of selected cytokines identified CD4 super(+) cells as the regulatory cells in the cotransfer inoculum; however, significant reduction in lesion severity was observed only when there was a concomitant increase in levels of IL-7. The role of IL-7 was further supported in that mice cotransferred with Skn-immune cells plus normal spleen cells, but also treated with anti-IL-7 Ab, no longer exhibited reduced lesion severity. To determine whether IL-7 expression without normal spleen cell cotransfer could modulate lesion development, an IL-7-encoding plasmid (pCMV-Tag1-IL-7) was topically delivered to sites flanking the stressed skin site in Skn-induced autoimmune mice. Daily application of 15 mu g of pCMV-Tag1-IL-7 significantly suppressed lesion severity. Our results support a mechanism for CD4 super(+) T cells and IL-7 in contributing to the control of autoreactivity.

    LA:

    Language
    English

    SL:

    Summary Language
    English

    PY:

    Publication Year
    2006

    PT:

    Publication Type
    Journal Article

    PB:

    Publisher
    American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, http://www.jimmunol.org/

    CL:

    Classification
    F 06360 Skin: Animal

    UD:

    Update
    200604

    SF:

    Subfile
    Immunology Abstracts

    AN:

    Accession Number
    6748692

    PG:

    Journal Pages
    3978-3986

    JV:

    Journal Volume
    176

    JI:

    Journal Issue
    7

Field Codes
    The following field codes are found in the records of this database. Here they are listed in alphabetical order by two-letter code. See Field Codes and Search Examples for detailed descriptions and search examples.

    AB = Abstract LA = Language
    AF = Author Affiliation NT = Notes
    AN = Accession Number NU = Other Numbers
    AU = Authors OT = Original Title
    CA = Corporate Author PB = Publisher
    CF = Conference PT = Publication Type
    CL = Classification Code PY = Publication Year
    DE = Descriptors SF = Subfile Name
    ED = Editor SL = Summary Language
    ER = Environmental Regime SO = Source
    IB = ISBN TI = Title
    ID = Identifiers TR = ASFA Input Center Number
    IS = ISSN UD = Update
 
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