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Industrial and Applied Microbiology Abstracts (Microbiology A)

 
 
Significant findings and practical applications in agricultural, food and beverage, chemical, and pharmaceutical industries are assembled in this journal, making it an indispensable resource for research laboratories and academic libraries in any of these areas.

Subject Coverage
    Major areas of coverage include:
    • Fermentation
    • Microbial Degradation
    • Food Microbiology
    • Microbial Toxins
    • Plant Diseases
    • Post-Harvest Decay
    • Plant Protection
    • Forestry
    • Soil Microorganisms
    • Mineral Microbiology
    • Protection of Materials
    • Hydrocarbons
    • Microbial Resistance
    • Antimicrobial Agents
Dates of Coverage
    1982 - current
Update Frequency
    Monthly, with approximately 880 new records added
Size
    Over 0 records as of May 2013
Print Equivalent
    Microbiology Abstracts Section A: Industrial and Applied Microbiology
Supplier
    Proquest
    789 E. Eisenhower Parkway
    P.O. Box 1346
    Ann Arbor, MI 48106-1346
    Tel: +1-734-761-4700
Sample Record

    TI:

    Title
    Immune Modulation by Cadmium and Lead in the Acute Reporter Antigen-Popliteal Lymph Node Assay

    AU:

    Author
    Carey, John B; Allshire, Ashley; van Pelt, Frank N

    AF:

    Author Affiliation
    Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland

    SO:

    Source
    Toxicological Sciences [Toxicol. Sci.]. Vol. 91, no. 1, pp. 113-122. May 2006.

    IS:

    ISSN
    1096-6080

    DE:

    Descriptors
    Metals; Hypersensitivity; Lymphocytes T; Lymph nodes; Immunoglobulin G; Lead; Adjuvants; Cadmium; Autoimmunity; Immunotoxicity; Toxins; Mercury; Lymphocytes B; Immunomodulation; Heavy metals

    AB:

    Abstract
    Immune modulation by heavy metals may cause serious adverse health effects in humans, although the mechanisms involved are not well understood. Both cadmium and lead are important environmental and occupational toxins. Therefore, in the current study, the costimulatory/adjuvant effects and the T-cell-activating potential of these metals (i.e., CdCl sub(2) and PbCl sub(2)), are examined. These immune-modulating properties are critical in the development of conditions such as allergy, hypersensitivity, and autoimmunity. Using the direct popliteal lymph node assay (PLNA) and reporter antigen-popliteal lymph node assay (RA-PLNA) both metals were examined individually for immunotoxicity. Mercury (i.e., HgCl sub(2)) was included for comparative purposes as its effects in the RA-PLNA are well documented. Seven days following a single footpad injection containing metal and/or RA (trinitrophenyl-ovalbumin [TNP-OVA] or TNP-Ficoll), BALB/c mice were sacrificed and the popliteal lymph nodes (PLNs) removed. PLN cellularity, TNP-specific antibody-secreting cells (ASCs), and lymphocyte subsets were assessed. All three metals strongly stimulated T- and B-cell proliferation and ASC production following coinjection with the RA TNP-OVA. In each case, ASC production was skewed towards the IgG sub(1) isotype. In addition, all three metals induced IgG production to TNP-Ficoll (although relatively weakly in the case of Cd). These results show that each of these metals can provide adjuvant signals to promote lymphocyte proliferation and enhance adaptive immune responses to unrelated antigens. Skewing of immune responses towards T helper type 2 responses suggests that each of these metals can enhance allergic and hypersensitivity reactions to environmental antigens. Furthermore, the induction of IgG responses to TNP-Ficoll, a T-cell-independent antigen, indicates that each of these metals can activate neoantigen-specific T cells. T-cell activation by metals can lead to metal hypersensitivity and has been implicated in the development of autoimmunity. This is the first report of immune modulation by CdCl sub(2) and PbCl sub(2) in the RA-PLNA.

    LA:

    Language
    English

    SL:

    Summary Language
    English

    PY:

    Publication Year
    2006

    PD:

    Publication Date
    200605

    PT:

    Publication Type
    Journal Article

    PB:

    Publisher
    Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, jnl.samples@oup.co.uk, http://www3.oup.co.uk/jnls/

    CL:

    Classification
    X 24222 Analytical procedures

    UD:

    Update
    200604

    SF:

    Subfile
    Toxicology Abstracts

    AN:

    Accession Number
    6753274

    PG:

    Journal Pages
    113-122

    JV:

    Journal Volume
    91

    JI:

    Journal Issue
    1

Field Codes
    The following field codes are found in the records of this database. Here they are listed in alphabetical order by two-letter code. See Field Codes and Search Examples for detailed descriptions and search examples.

    AB = Abstract LA = Language
    AF = Author Affiliation NT = Notes
    AN = Accession Number NU = Other Numbers
    AU = Author OT = Original Title
    CA = Corporate Author PB = Publisher
    CF = Conference PT = Publication Type
    CL = Classification Code PY = Publication Year
    DE = Descriptors SF = Subfile Name
    ED = Editor SL = Summary Language
    ER = Environmental Regime SO = Source
    IB = ISBN TI = Title
    ID = Identifiers TR = ASFA Input Center Number
    IS = ISSN UD = Update