TOXLINE on this service offers rapid access to information in all areas of toxicology, including chemicals and pharmaceuticals, pesticides, environmental pollutants, and mutagens and teratogens. This database, produced by the U.S. National Library of Medicine, provides bibliographic citations and abstracts from the core journal literature in toxicology. This version of TOXLINE does not contain information from Chemical Abstracts Service, BIOSIS, or International Pharmaceutical Abstracts.
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Major areas of coverage include:
- Air pollution
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- Biological and adverse effects of drugs
- Carcinogenesis via chemicals
- Chemically-induced diseases
- Environmental chemicals and pollutants
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- Genotoxicity
- Hazardous materials
- Health and safety
- Human and animal toxicity
- Industrial and household chemicals
- Mutagenicity Pesticides and herbicides
- Radioactive materials
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| TI: |
Title
Relationship of serum TCDD concentrations and age at exposure
of female residents of Seveso, Italy. |
| AU: |
Author
Eskenazi, B;
Mocarelli, P; Warner,
M; Needham, L;
Patterson, DG Jr; Samuels,
S; Turner, W; Gerthoux,
PM; Brambilla, P |
| AF: |
Author Affiliation
School of Public Health, University of California at Berkeley,
2150 Shattuck Avenue, Berkeley, CA 94720-7380, USA. eskenazi@uclink.berkeley.edu |
| SO: |
Source
Environmental health perspectives, 2004 Jan, 112(1):22-7 |
| IS: |
ISSN
0091-6765 |
| AB: |
Abstract
In 1976, a chemical plant explosion near Seveso, Italy, resulted
in the highest known exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) in residential populations. In 1996, we initiated the Seveso
Women's Health Study (SWHS), a historical cohort study of females
who were 40 years old at the time of explosion and residents of
the most heavily contaminated areas, zones A and B. Serum samples
collected near the time of the explosion were analyzed for TCDD.
We also analyzed pooled serum samples collected in 1976 from females
who resided in zone non-ABR, the "unexposed" zone, to
assess concurrent background exposures to other dioxins, furans,
and coplanar polychlorinated biphenyls (PCBs). The median lipid-adjusted
TCDD level for residents of zones A and B combined was 56 ppt
(range = 2.5-56,000 ppt). Zone A residents had 5-fold higher TCDD
levels (n = 67, median = 272 ppt) than did zone B residents (n
= 814, median = 47 ppt). The youngest children had the highest
TCDD levels, which decreased with age at explosion until approximately
13 years of age and were constant thereafter. Therefore, children
living in zones A and B received a disproportionately higher exposure
to TCDD as a result of the explosion. Zone of residence and age
were the strongest predictors of TCDD level. Chloracne, nearby
animal mortality, location (outdoors vs. indoors) at the time
of explosion, and consumption of homegrown food were also related
to serum TCDD levels. The serum pools from zone non-ABR residents
had an average TCDD concentration of 20.2 ppt, and average total
toxic equivalent (TEQ) concentration of 100.4 ppt. Therefore,
background exposure to dioxins, furans, and PCBs unrelated to
the explosion may have been substantial. As a consequence, previous
SWHS studies that considered only TCDD exposure may have underestimated
health effects due to total TEQ concentrations. |
| LA: |
Language
English |
| PY: |
Publication Year
2004 |
| PT: |
Publication Type
Journal Article |
| DE: |
Descriptors
Accidents, Occupational; Adolescent; Adult;
Age Factors; Chemical Industry;
Child;
Child Welfare; Child, Preschool;
Cohort Studies;
Diet; Environmental Exposure;
Explosions;
Female; Food Contamination;
Human; Infant; Infant, Newborn;
Italy; Risk Assessment; Support,
Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.;
Support, U.S. Gov't, P.H.S.; Teratogens: analysis;
Tetrachlorodibenzodioxin: blood |
| RN: |
Registry Number
0 (Teratogens); 1746-01-6 (Tetrachlorodibenzodioxin) |
| GI: |
Grant
Grant/Contract ID: 2P30 ES 001896-17 (NIEHS); R01 ES 07171 (NIEHS) |
| UD: |
Update
20040506 |
| RO: |
Record Owner
National Library of Medicine |
| AN: |
Accession Number
14698926 |
Field Codes
The following field codes are found in the records of this database.
Here they are listed in alphabetical order by two-letter code. See Field Codes and Search Examples for detailed
descriptions and search examples.
| AB = Abstract |
LA = Language |
| AF = Author Affiliation |
LR = Last Revision Date |
| AN = Accession Number |
NT = Notes |
| AU = Author |
OT = Original Title |
| CP = Country of Publication |
PT = Publication Type |
| DB = Databank |
PY = Publication Year |
| DE = Descriptors |
RN = Registry Number |
| EE = Electronic Publication Date |
RO = Record Owner |
| FE = Features |
RP = Report Number |
| GI = Grant Information |
SF = Subfile |
| ID = Identifiers |
SM = Space Flight Mission |
| IR = Investigator |
SO = Source |
| IS = ISSN |
TI = Title |
| JN = Journal Name |
UD = Update |
|
