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Virology and AIDS Abstracts

 
 
Virology research has become more important than ever, as scientists around the globe race to overcome the deadly challenge of Acquired Immune Deficiency Syndrome - while ongoing projects continue the quest for answers in other crucial areas of virology. Now expanded to highlight AIDS studies in every issue, Virology and AIDS Abstracts provides a month-by-month summary of the myriad findings in this information-intensive research race. Comprehensive coverage of the world literature on every aspect of virology in humans, animals, and plants is featured, with topics ranging from replication cycles to oncology. The same comprehensive treatment is devoted to such topics as hepatitis B virus vaccination, viral genetics, interferon, and more - demonstrating the breadth of coverage that has long helped researchers meet the challenges of this field.

Subject Coverage
    Major areas of coverage include:
    • Acquired Immune Deficiency Syndrome
    • Virus Taxonomy and Classification
    • Methodology and Tissue Culture Studies
    • Physico- Chemical Properties, Structure, and Morphology
    • Replication Cycle
    • Viral Genetics Including Virus Reactivation
    • Phage-Host Interactions Including Lysogeny and Transduction
    • Immunology
    • Antiviral Agents
    • Oncology
    • Viral Infections of Man
    • Diseases Associated with Slow Viruses
    • Viral Infections of Animals
    • Animal Models and Experimentally-Induced Viral Infections
    • Viral Infections of Invertebrates
    • Viral Infections of Fungi and Lower Plants
    • Viral Infections of Higher Plants
Dates of Coverage
    1982 - current
Update Frequency
    Monthly, with approximately 940 new records added
Size
    Over 0 records as of May 2013
Print Equivalent
    Virology and AIDS Abstracts
Supplier
    Proquest
    789 E. Eisenhower Parkway
    P.O. Box 1346
    Ann Arbor, MI 48106-1346
    Tel: +1-734-761-4700
Sample Record

    TI:

    Title
    The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity

    AU:

    Author
    Jacque, Jean-Marc; Stevenson, Mario

    AF:

    Author Affiliation
    Program in Molecular Medicine, University of Massachusetts Medical School , 373 Plantation Street, Suite 319, Worcester, Massachusetts 01605, USA mario.stevenson@umassmed.edu

    SO:

    Source
    Nature [Nature]. Vol. 441, no. 7093, pp. 641-645. Jun 2006

    IS:

    ISSN
    0028-0836

    DE:

    Descriptors
    Infection; Macrophages; cDNA; Chromatin; Nuclear membranes; emerin; HIV-1; Human immunodeficiency virus 1

    AB:

    Abstract
    Primate lentiviruses such as human immunodeficiency type 1 (HIV-1) have the capacity to infect non-dividing cells such as tissue macrophages. In the process, viral complementary DNA traverses the nuclear envelope to integrate within chromatin. Given the intimate association between chromatin and the nuclear envelope, we examined whether HIV-1 appropriates nuclear envelope components during infection. Here we show that emerin, an integral inner-nuclear-envelope protein, is necessary for HIV-1 infection. Infection of primary macrophages lacking emerin was abortive in that viral cDNA localized to the nucleus but integration into chromatin was inefficient, and conversion of viral cDNA to non-functional episomal cDNA increased. HIV-1 cDNA associated with emerin @@iin vivo@, and the interaction of viral cDNA with chromatin was dependent on emerin. Barrier-to-autointegration factor (BAF), the LEM (LAP, emerin, MAN) binding partner of emerin, was required for the association of viral cDNA with emerin and for the ability of emerin to support virus infection. Therefore emerin, which bridges the interface between the inner nuclear envelope and chromatin, may be necessary for chromatin engagement by viral cDNA before integration.

    LA:

    Language
    English

    SL:

    Summary Language
    English

    PY:

    Publication Year
    2006

    PD:

    Publication Date
    200606

    PT:

    Publication Type
    Journal Article

    PB:

    Publisher
    Nature Publishing Group, The Macmillan Building, 4 Crinan Street, London, N1 9XW, UK; feedback@nature.com

    DO:

    DOI
    10.1038/nature04682

    CL:

    Classification
    N 14025 RNA/DNA role in infection & immune response; V 22002 AIDS: Molecular and in vitro aspects

    UD:

    Update
    200607

    SF:

    Subfile
    Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts

    AN:

    Accession Number
    6854954

    PG:

    Journal Pages
    641-645

    JV:

    Journal Volume
    441

    JI:

    Journal Issue
    7093

Field Codes
    The following field codes are found in the records of this database. Here they are listed in alphabetical order by two-letter code. See Field Codes and Search Examples for detailed descriptions and search examples.

    AB = Abstract IS = ISSN
    AF = Author Affiliation LA = Language
    AN = Accession Number NT = Notes
    AU = Authors NU = Other Numbers
    CA = Corporate Author OT = Original Title
    CF = Conference PB = Publisher
    CL = Classification Code PT = Publication Type
    DE = Descriptors PY = Publication Year
    ED = Editor SF = Subfile Name
    EM = Entry Month SL = Summary Language
    ER = Environmental Regime SO = Source
    IB = ISBN TI = Title
    ID = Identifiers TR = ASFA Input Center Number